张慧

日期: 2021/01/27 作者: 浏览量:


张慧教授

简介:

张慧,1963年8月出生,湖南华容人,民盟盟员。生命科学学院教授,硕士研究生及博士研究生导师。从事植物耐盐机理、C4光合机制研究工作,目前主要从事藜麦资源收集、育种与示范种植工作。1994年获西北农林科技大学植物病理学博士学位,1998年担任博士生导师。主持完成国家“973”项目2项、国家“863”项目2项、国家自然科学基金面上项目3项以及山东省重点攻关等重大科研项目。目前正承担山东省自然科学基金面上项目1项以及藜麦育种与产业化科研项目1项。在“plant physiology”等国际著名期刊发表SCI论文达50多篇。分别于1998年,应日本学术振兴会邀请访问筑波理化研究所、东京大学等10余家从事植物分子生物学研究的著名实验室。1999年赴美国亚利桑那大学朱健康教授实验室进行短期合作研究,2003年赴美国加州大学戴维斯分校E. Blumwald教授实验室从事客座研究,2004年短期访问以色列本·古里安大学,2008年、2009年赴英国爱丁堡大学从事客座研究工作。2015年始,中国科学院逆境植物研究中心访问教授。山东省十大优秀青年,山东师范大学中青年学术骨干培养对象,校十佳青年。2009年获山东省自然科学奖一等奖(第三位)、2009年山东省研究生教学成果一等奖(第八位)。曾任生命科学学院副院长,山东省逆境植物重点实验室主任、副主任,山东师范大学特聘教授。

研究方向:

1.开展盐生植物分子生物学研究,特别是首创盐芥作为植物耐盐模式研究系统。

2. C4光合的进化机制研究。

3.开展泌盐经济作物藜麦的耐盐遗传机理以及种质创新研究

开设的课程:

植物分子生物学、表观遗传学、现代分子生物学技术、系统生物学等硕士、博士研究生课程。

承担的主要项目:

1.抗盐、耐海水植物的滩涂规模化种植技术,国家863(课题组长), 1998-2000, 60万

2.植物耐盐基因工程新途径的研究,青年863, 1999-2001, 15万

3.盐生植物耐盐分子机制,国家973, 1999-2003, 333.5万(PI)

4.植物耐盐基因工程新途径,国家自然科学基金, 2000-2002, 14万

5.盐地碱蓬盐诱导NCED基因及其启动子的克隆与鉴定(30270741/C0601), 2003-2005, 20万元

6.盐地碱蓬耐盐新基因的克隆与鉴定((2004AA626060),国家863(课题组长), 2004-2005, 90万

7.特殊生境资源植物中重要耐盐、耐低温基因的克隆与功能研究,国家973, 2006-2010, 440万(PI)

8.耐盐植物耐盐机理研究、耐盐基因的克隆及转基因耐盐植物的构建(2007DFA30630)中澳合作项目子课题2007-2010, 30万

9.小盐芥耐盐碱功能基因的开发与利用(2007AA021402)子课题国家863 2007-2010, 30万

10.盐芥磷高效利用的生理与遗传学基础(30770180)国家自然科学基金2008-2010, 30万

11.盐芥、碱蓬抗旱、耐盐基因的克隆与功能分析,山东省良种工程子课题,山东省科技厅,2014,30万元,主持。

12.盐生植物珍珠猪毛菜C4综合性状的发育遗传机制(ZR2018MC001),山东省自然基金面上项目,山东省科技厅,2018/03- 2021/6,15万元,主持。

13.藜麦育种与产业化科研项目齐河县县政府,2019.01-2023.12,3000万元,主持。

主要科研成果:

代表性论文:

1. Qinghua Qiao*, Jingxia Zhang*, Changle Ma*, Furong Wang, Yu Chen, Chuanyun Zhang,Hui Zhang*, Jun Zhang*. Characterization and variation of the rhizosphere fungal community structure of cultivated tetraploid cotton.PLoS ONE. 2019, 14(10): e0207903. ttps://doi.org/10.1371/journal. pone.0207903

2. Yan Li, Wei Sun, Fulin Liu, Jin Cheng, Xiaojie Zhang,Hui Zhangand Yanxiu Zhao。Methods for grafting Arabidopsis thaliana and Eutrema salsugineum. Plant Methods. 2019, 15:93. https://doi.org/10.1186/s13007-019-0477-x

3. Changsong Zou, Leiting Li, Daisuke Miki, Delin Li, Qiming Tang, Lihong Xiao, Santosh Rajput, Ping Deng, Li Peng, Wei Jia, Ru Huang, Meiling Zhang, Yidan Sun, Jiamin Hu, Xing Fu, Patrick S. Schnable , Yuxiao Chang, Feng Li,Hui Zhang, Baili Feng, Xinguang Zhu, Renyi Liu , James C. Schnable, Jian-Kang Zhu*, Heng Zhang*. The genome of broomcorn millet. Nature Communications. 2019;10(1):436.

4.Xiangqiang Kong,Xue Li,Hequan Lu,Zhenhuai Li,Shizhen Xu,Weijiang Li,Yanjun Zhang,Hui Zhang,Hezhong Dong.Monoseeding improves stand establishment through regulation of apical hook formation and hypocotyl elongation in cotton. Field Crops Research, 2018, 222:50-58.

5. Changsong Zou, Aojun Chen, Lihong Xiao, Heike M Muller, Peter Ache, Georg Haberer, Meiling Zhang, Wei Jia, Ping Deng, Ru Huang, Daniel Lang, Feng Li, Dongliang Zhan, Xiangyun Wu,Hui Zhang, Jennifer Bohm, Renyi Liu, Sergey Shabala, Rainer Hedrich, Jian-Kang Zhu, Heng Zhang. A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value. Cell Research. 2017, 27:1327-1340.

6. Qinghua Qiao, Furong Wang, Jingxia Zhang, Yu Chen, Chuanyun Zhang, Guodong Liu,Hui Zhang, Changle Ma & Jun Zhang. The variation in the rhizosphere microbiome of cotton with soil type, genotype and developmental stage. Sci Rep. 2017, 7(1):3940. doi: 10.1038/s41598-017-04213-7.

7. Xiaofeng Song, Haichao Wei, Wen Cheng, Suxin Yang, Yanxiu Zhao,* Xuan Li, Da Luo,Hui Zhang,* and Xianzhong Feng. Development of INDEL markers for genetic mapping based on whole genome resequencing in soybean.G3 (Bethesda).2015, 5(12):2793-2799.

8.宋晓峰,司晓娇,沈晓艳,魏海超,孙伟,冯献忠,张慧,王增兰.盐芥和拟南芥在不同胁迫下生理及ABA受体基因的响应[J].植物生理学报, 2015(8):1248-1256.

9. Yuanyuan Li*, Xiuling Ma, Jialei Zhao, Jiajia Xu, Junfeng Shi, Xin-Guang Zhu, Yanxiu Zhao,Hui Zhang.Developmental Genetic Mechanisms of C4 Syndrome Based on Transcriptome Analysis of C3 Cotyledons and C4 Assimilating Shoots in Haloxylon ammodendron,PLOS ONE,2015,10(7): doi:10.1371/ journal. pone. 0117175. (IF: 3.234, JCR分区:一区)

10. Wei Sun, Yan Li, Yanxiu Zhao andHui Zhang. The TsnsLTP4, a nonspecific ipid transfer protein involved in wax deposition nd stress tolerance. Plant Molecular Biology Reporter, 2014.

11. Xiaoyan Shen, Zenglan Wang, Xiaofeng Song, Jiajia Xu, Chunyun Jiang,Yanxiu Zhao, Changle Ma andHui Zhang. Transcriptomic profiling revealed an important role of cell wall remodeling and ethylene signaling pathway during salt acclimation in Arabidopsis. Plant Mol Biol. 2014, 86:303–317.

12. Xu J, Li Y, Ma X, Ding J, Wang K, Wang S, Tian Y,Zhang H, Zhu XG. Whole transcriptome analysis using next-generation sequencing of model species Setaria viridis to support C4 photosynthesis research.Plant Molecular Biology. 2013. 83: 77-87 (IF: 4.257, JCR分区:一区)

13. Zhibin Sun, Xingyun Qi, Zenglan Wang, Pinghua Li, Chunxia Wu,Hui Zhang, Yanxiu Zhao. Overexpression of TsGOLS2, a galactinol synthase, in Arabidopsis thaliana enhances tolerance to high salinity and osmotic stresses. Plant physiology and biochemistry. 2013, 69: 82-89. SCI

14. Lei Hou, Longjun Chen, Junyi Wang, Dongfang Xu, Lixin Dai,Hui Zhangand Yanxiu Zhao. Construction of Stress Responsive Synthetic Promoters and Analysis of Their Activity in Transgenic Arabidopsis thaliana. Plant Mol Biol Rep. 2012, 30:1496–1506.

15.Xiangqiang Kong,Xiuhua Gao,Wei Sun,Jing An,Yanxiu ZhaoandHui Zhang. Cloning and functional characterization of a cation–chloride cotransporter geneOsCCC1.Plant Molecular Biology, 2011,75( 6): 567-578.

16. Jingxia Zhang, Cui Wang, Chuanyan Yang, Jiaying Wang, Lei Chen, Xiaoming Bao, Yanxiu Zhao,Hui Zhangand Jian Liu*. The role of arabidopsis AtFes1A in cytosolic Hsp70 stability and abiotic stress tolerance,Plant Journal, 2010, 62: 539–548. SCI (一区)

17. Weihuan Li, Quan Zhang, Xiangqiang Kong, Chunxia Wu, Xiuling Ma,Hui Zhang& Yanxiu Zhao. Salt tolerance is conferred in Arabidopsis by overexpression of the vacuolar Na+/H+antiporter gene SsNHX2, an alternative splicing variant of SsNHX1, from Suaeda salsa.Journal of Plant Biology, 2009, 52(2):147-134.

18. Chunxia Wu & Xiuhua Gao & Xiangqiang Kong &Yanxiu Zhao &Hui Zhang.Molecular cloning and functional analysis of a Na+/H+ antiporter GeneThNHX1from a halophytic plantThellungiella halophila. Plant Molecular Biology Reporter. 2009, 27:1–12.

19. Xiangqiang Kong, xiuhua Gao, Weihuan Li, Jiqiang Zhao, Yanxiu Zhao andHui Zhang. Overexpression ofENA1from Yeast Increases Salt Tolerance inArabidopsis.Journal of Plant Biology, 2008, 51(2): 159-165

20. Zhibin Sun, Xingyun Qi, Pinghua Li, Chunxia Wu, Yanxiu Zhao,Hui Zhangand Zenglan Wang. Overexpression of a Thellungiella halophila CBL9 Homolog, ThCBL9 Confers Salt and Osmotic Tolerances in TransgenicArabidopsis thalianaJournal of Plant Biology, 2008, 51(1):25-34 2007

21. Shihua Chen, Shanli Guo, Zenglan Wang, Jiqiang Zhao, Yanxiu Zhao,Hui Zhang. 2007. Expressed sequence tags from the halophyte Limonium sinense.DNA Sequence, 18(1):61-67.

22. Wei Sun, Ziyi Cao, Yan Li, Yanxiu Zhao andHui Zhang. A simple and effective method for protein subcellular localization using Agrobacterium -mediated transformation of onion epidermal cells. Biologia, 2007, 62(5):529-532.

23. Fengyun Zhao,Hui Zhang. Salt and paraquat stress tolerance results from co-expression of the Suaeda salsa glutathione S-transferase and catalase in transgenic rice Plant Cell Tiss Organ Cult, 2006, 86: 349-358

24. Fengyun Zhao, Xuejie Zhang, Pinghua Li, Yanxiu Zhao,Hui Zhang. Co-expression of the Suaeda salsa SsNHX1 and Arabidopsis AVP1 confer greater salt tolerance to transgenic rice than the single SsNHX1. Mol Breeding, 2006, 17:341-353.

25. Shanli Guo, Haibo Yin, Xia Zhang, Fengyun Zhao, Pinghua Li, Shihua Chen, Yanxiu Zhao andHui Zhang. Molecular cloning and characterization of a vacuolar H+-pyrophosphatase gene, SsVP, from the halophyte Suaeda salsa and its overexpression increases salt and drought tolerance of Arabidopsis. Plant Molecular Biology, 2006, 60:41-45.

26. Fengyun Zhao, Shanli Guo,Hui Zhang, Yanxiu Zhao. Expression of yeast SOD2 in transgenic rice results in increased salt tolerance. Plant Science, 2006,170:216-224.

27. Liwen Jing, Shihua Chen, Xiaoli Guo,Hui Zhangand Yanxiu Zhao. Overexpression of a Chloroplast-located Peroxiredoxin Q Gene, SsPrxQ, Increases the Salt and Low-temperature Tolerance of Arabidopsis. Journal of Integrative Plant Biology, 2006, 48(10):1244-1249.

28. Yangrong Cao, Xiaoli Guo, Quan Zhang, Ziyi Cao, Yanxiu Zhao andHui Zhang. Isolation and characterization of carotenoid cleavage dioxygenase gene in halophyte Suaeda salsa. Plant Growth Regulation, 2005, 46:61-67.

29. Xiuling Ma, Quan Zhang, Huazhong Shi, Jian-Kang Zhu, Yanxiu Zhao, Changle Ma,Hui Zhang. Molecular cloning and expression analysis of the antiporter in Suaeda salsa. Biologia Plantrum, 2004, 48: 219-225.

30. Xia Zhang, Shanli Guo, Haibo Yin, Dongjin Xiong,Hui Zhang, Yanxiu Zhao. Molecular Cloning and Identification of a Heat Shock Cognate Protein 70 Gene, Thhsc70, in Thellungiella halophila. Acta Botanica Sinica(植物学报), 2004, 46(10):1212-1219.

31. Günsu Inan, Quan Zhang, Pinghua Li, Zenglan Wang, Ziyi Cao,Hui Zhang, Changqing Zhang, Tanya M.Quist, S. Mark Goodwin, Jianhua Zhu, Huazhong Shi, Barbara Damsz, Tarif Charbaji, Qingqiu Gong, Shisong Ma, Mark Fredricksen, David W. Galbraith, Matthew A. Jenks, David Rhodes, Paul M. Hasegawa, Hans J. Bohnert, Robert J. Joly, Ray A. Bressan, Jian-Kang Zhu. Salt Cress. A Halophyte and Cryophyte Arabidopsis Relative Model System and Its Applicability to Molecular Genetic Analyses of Growth and Development of Extremophiles. Plant Physiology, 2004, 135: 1718-1737.

32. Xiaoli Guo, Yangrong Cao, Ziyi Cao, Yanxiu Zhao,Hui Zhang.Molecular cloning and characterization of a stress-induced peroxiredoxin Q gene in halophyte Suaeda salsa. Plant Science, 2004,167: 969-975

33. Zenglan Wang, Pinghua Li, Mark Fredricksen, Zhi-zhong Gong, C.S. Kim, Changquing Zhang, Hans J. Bohnert, Jian-Kang Zhu, Ray A. Bressan, Paul M. Hasegawa, Yanxiu Zhao,Hui Zhang. Expressed sequence tags from Thellungiella halophila, a new model to study plant salt-toleranc. Plant Science, 2004,166: 609–616.

34. Xiuhua Gao, Zhonghai Ren, Yanxiu Zhao,Hui Zhang. Overexpression of SOD2 Increases Salt Tolerance of Arabidopsis, Plant Physiology, 2003,133(12):1873–1881.

35. Xiuling Ma, Zenglan Wang, Yuancheng Qi, Yanxiu Zhao,Hui Zhang. Isolation of S-adenosylmethionine Synthetase Gene from Suaeda salsa and Its Differential Expression Under NaCl Stress. Acta Botanica Sinica(植物学报), 2003, 45: 1359-1365.

36. Changle Ma, Pingping Wang, Ziyi Cao, Yanxiu Zhao,Hui Zhang. Cloning and Differential Gene Expression of Two Catalase in Suaeda salsa in Response to Salt Stress. Acta Botanica Sinica(植物学报), 2003, 45:93-97.

37. Xiaojun Yin, Yanxiu Zhao, Da Luo,Hui Zhang. Isolation the promoter of a stress-induced gene encoding betaine aldehyde dehydrogenase from the halophyte Atriplex centralasiatica Iljin. Biochimica et Biophysica Acta (BBA), 2002, 1577(3): 452-456.

38. Ray A. Bressan, Changqing Zhang,Hui Zhang, Paul M. Hasegawa, Hans J. Bohnert and Jian-Kang Zhu. Learning from the Arabidopsis Experience. The Next gene search paradigm. Plant Physiol, 2001, 127(4):1354-1360.

39. Lei Zhang, Xiuling Ma, Quan Zhang, Changle Ma, Pingping Wang,Yufei Sun, Yanxiu Zhao,Hui Zhang. Expressed sequence tags from NaCl-treated Suaeda salsa cDNA Library. Gene, 2001,267:193-200.

40. Suxin Yang, Yanxiu Zhao, Quan Zhang, Yuke He,Hui Zhang, Da Luo. HAL1 mediate salt adaptation in Arabidopsis thaliana. Cell Research 2001,11(2):142-148.

获奖:

科研奖:

2009年获山东省自然科学奖一等奖(第三位)

教学奖:

2009年山东省研究生教学成果一等奖(第八位)。

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