李国荣

日期: 2021/01/30 作者: 浏览量:



一、个人简介

李国荣,教授 博士博士生导师。

教育经历:

1981-1985 山东师范大学生物系,本科生

1985-1988 山东师范大学生物系,动物学硕士研究生

1997-2000 中国科学院海洋研究所,海洋生物博士研究生

工作经历:

1987-2001山东师范大学生物系,助教、讲师、副教授

2001-2003Post-doctoral Research Associate, Kumamoto University, Japan

2003-2004山东师范大学生命科学学院,教授

2004-2009Visiting Fellow, National Cancer Institute, National Institutes of Health, USA

2009-2013山东师范大学生命科学学院,教授、博士生导师

2013-2014Visiting Fellow, Warwick University, UK

2014-至今山东师范大学生命科学学院,教授、博士生导师

二、研究方向:

1、抗癌药物抑制癌细胞增殖和迁移的信号转导通路研究

2、抗衰老药物延缓硬骨鱼衰老延长寿命的作用机理研究

三、教学科研成果

代表性论文:

1. Wei JT, Qi H, Liu KK, Zhao CS, Bian Y,Li GR*. Effects of Metformin on Life Span, Cognitive Ability, and Inflammatory Response in a Short-Lived Fish. J Gerontol A Biol Sci Med Sci. 2020, glaa109.

2. Zheng ZD, Bian Y, Zhang Y, Ren GH,Li GR*. Metformin Activates AMPK/SIRT1/NF-κB Pathway and Induces Mitochondrial Dysfunction to Drive caspase3/GSDME-mediated Cancer Cell Pyroptosis.. Cell Cycle. 2020, 19(10):1089-1104.

3. Bian Y, Wei JD, Zhao CS,Li GR*. Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer. Int J Mol Sci. 2020, 21(2). pii: E684.

4. Zheng ZD,Li GR*. Mechanisms and Therapeutic Regulation of Pyroptosis in Inflammatory Diseases and Cancer. Int J Mol Sci. 2020, 21(4). pii: E1456.

5. Zhang Y,Li GR*.A tumor suppressor DLC1: The functions and signal pathways. J Cell Physiol. 2020, 235(6):4999-5007. doi: 10.1002/jcp.29402. Epub 2019 Nov 26.

6. Liu S, Zheng Z, Ji S; Liu T, Hou Y, Li S,Li GR*. Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fishNothobranchius guentheri.Fish and Shellfish Immunology.80:473-479, 2018.

7. Ji S,, Zheng Z, Liu S, Ren G, Gao J, Zhang Y,Li GR*. Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells. Exp Cell Res. 370(2):292-302, 2018.

8.Liu T, Liu S, Ma L, Li F, Zheng Z, Chai R, Hou Y, Xie Y,Li GR*,Oogenesis, vitellogenin-mediated ovarian degeneration and immune response in the annual fish Nothobranchius guentheri. Fish & Shellfish Immunology 66: 86-92. 2017

9. Liu T, Ma L, Zheng Z, Li F, Liu S, Xie Y,Li GR*. Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fsh Nothobranchius guentheri. Oncotarget 8(33):55422-55434. 2017.

10.Yang B,Zhu W,Zheng Z,Chai R,Ji S,Ren G,Liu T,Liu Z,Song T,Li F,Liu S,Li GR*,Fluctuation of ROS regulates proliferation and mediates inhibition of migration by reducing the interaction between DLC1 and CAV-1 in breast cancer cells.In Vitro Cell Dev Biol Anim. 53(4):354-362. 2017

11.Zhu W,Ma L,Yang B,Zheng Z,Chai R,Liu T,Liu Z,Song T,Li F,Li GR*Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells.In Vitro Cell Dev Biol Anim. 52(5):589-97. 2016

12.Liu T, Qi H, Ma L, Liu Z, Fu H, Zhu W, Song T, Yang B,Li GR*.Resveratrol attenuates oxidative stress and extends lifespan in the annual fish Nothobranchius Guentheri. Rejuvenation Res.18(3):225-33.2015

13.Zhu W, Yang B, Fu H, Ma L, Liu T, Chai R, Zheng Z, Zhang Q,Li GR*.Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells. Biochemical and Biophysical Research Communications (BBRC). 458:590-595.2015

14. Ma L, Zhu W, Liu T, Fu H, Liu Z, Yang B, Song T,Li GR*, H2O2Inhibits Proliferation and Mediates Suppression of Migration via DLC1/RhoA Signaling in Cancer Cells. Asian Pac J Cancer Prev.16(4):1637-42.2015.

15.Yu X,Li GR*. Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fishNothobranchiusguentheri.Exp Gerontol. 47:940-949. 2012.

16.Li GR#, Du XL, Vass W, Papageorge A, Lowy DR* Qian X*.Full activity of the deleted in liver cancer1(DLC1)tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase(FAK).Proc Natl Acad Sci U S A(PNAS). 108(41):17129-17134. 2011.

17. Qian X,Li GR, Vass WC, Papageorge AG, Walker R, Asnaghi L, Steinbach PJ, Tosato G, Hunter K, Lowy DR*. The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.CANCER CELL; 16(3):246-58. 2009.

18.Qian X#, Li GR#,Asmussen HK,Asnaghi L,Vass WC,Braverman R,Yamada KM,Popescu NC,Papageorge AG,Lowy DR.Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.Proc Natl Acad Sci U S A.104(21):9012-7. 2007

主持和参与的研究课题:

1.国家自然科学基金项目:白藜芦醇通过SIRT1抑制假鳃自发肝脏肿瘤的作用及其表观遗传调控机制(31672377),主持。

2.国家自然科学基金项目:白藜芦醇通过SIRT1抑制肿瘤发生延缓贡氏假鳃鳉衰老的机理研究(31340035),主持。

3.山东省科技重大专项(重大关键技术)项目,肿瘤靶向药物筛选关键技术研究(项目编号2015ZDJS04003),第二位。

4.山东省自然科学基金重点项目:活性氧H2O2在乳腺癌细胞中调节RhoA活性的信号转导通路及作用机理研究(ZR2013CZ002),主持。

5.山东省科技发展计划项目:黄酮抑制乳腺癌增殖和迁移的研究(2012CSF12112),主持。

6.山东省自然科学基金项目:肿瘤抑制基因DLC-1通过talin的抑癌作用机理( ZR2009DM048),主持。

7.高等学校博士学科点专项科研基金(博导类):白藜芦醇对贡氏假鳃鳉体内活性氧和肿瘤发生的影响(20113704110004,2012-2014)

8.山东省高等学校科技计划项目:白藜芦醇对贡氏假鳃鳉寿命的延长作用研究( J09LC07,2010.1-2012.12)

四、荣誉、奖励及参加学术团体的情况:

2000获山东省优秀博士学位论文

2018指导的博士生获山东省优秀博士学位论文

2019获山东省优秀研究生指导教师

中国动物学会动物生理生态学分会委员、山东动物学会常务理事、山东细胞生物学会理事、

联系方式:

济南市文化东路88山东师范大学生命科学学院(250014

邮箱:grli@sdnu.edu.cn