赵国琰

日期: 2021/01/30 作者: 浏览量:



一、个人简介

1.姓名职称:

赵国琰,副教授,硕士生导师

2.教育经历:

2006/09-2011/07,山东大学,生命科学学院,博士

2002/09-2006/07,山东大学,生命科学学院,学士

3.工作经历:

2016/10-至今,山东师范大学,副教授

(期间2017/10-2019/09,英国约克大学,博士后)

2014/09-2016/09,山东师范大学,讲师

2011/07-2014/08,南京大学,助理研究员

4.社会兼职:

2020/06-至今,山东省留学人员协会,副秘书长

2019/10-至今,山东省微生物学会,理事

2018/10-至今,山东微生物学会科普工作委员会,委员

二、研究方向

1.植物内生细菌的生理生态功能研究

研究课题包括滨海湿地植物内生细菌介导植物表面微纳米锰氧化物的生物合成机制、内生细菌强化植物修复环境污染物的途径和机制、重要功能基因和酶的挖掘、内生细菌-植物的互作抗逆机制研究。

2.蓝细菌的细胞图谱及形态发生调控机制研究

细长聚球藻的高通量荧光标记和细胞定位技术研究、高通量缺失突变体筛选技术研究、蓝细菌细胞分裂和形态发生过程中的基因调节机制研究。

三、承担项目

1.山东省自然科学基金优秀青年基金:“黄河三角洲三种盐生植物内生细菌的分离鉴定及其促生耐盐机制研究”(2015ZRB01ALJ),2015.05-2016.12。

2.国家自然科学基金:“黄河三角洲盐生植物内生细菌在锰氧化物生物合成中的作用及分子机制研究”(31640002),2017.01-2017.12。

3.国家自然科学基金:“新型真菌漆酶LacTL对萘酚化合物的对映选择”(21302091),2014.01-2016.12。

4.国家863计划海洋技术领域主题项目子课题:“海洋微生物先导化合物的生物合成调控与产率优化”(2013AA092901),2013.01-2015.12。

5.江苏省自然科学基金:“真菌漆酶LACS的不对称C-C偶合功能研究”(BK2012308),2012.07-2015.06。

6.全国博士后派出项目:“湿地植物内生细菌介导宿主表面锰氧化膜合成的动态过程和分子机制研究”(20170058),2017.10-2019.09。

7.中国博士后科学基金面上资助:“湿地植物内生细菌在锰氧化物形成过程中的作用研究”(2016M600551),2016.10-2019.10。

8.生物反应器工程国家重点实验室开放课题:“新型免疫抑制剂Dalesconol的代谢调控与发酵优化” 2013.06-2015.05。

9.中央高校基本科研业务费:“Daldinia eschscholziiIFB-TL01所产漆酶lacTLs的对映选择性催化性质及机制研究” 2013.01-2013.12。

10.中央高校基本科研业务费苗圃项目:“新型真菌漆酶LacTL对萘酚化合物的对映选择性催化机制” 2014.01-2014.12。

四、教学科研成果(论文、专著、专利等)

1.发表文章(#第一作者,*通讯作者):

①Han S#, Han WB#, Chen J, Sun YK, Dai MX,Zhao GY*: Bioremediation of malachite green by cyanobacteriumSynechococcus elongatusPCC 7942 engineered with a triphenylmethane reductase gene.Applied Microbiology and Biotechnology2020. 104:3193–3204.

Zhao GY#*, Cheng JH#, Sun NN, Ma CL, Dai MX: Two endophytic bacterial strains modulate Mn oxidation and accumulation in the wetland plantSuaeda salsapall.Plant and Soil2019, 438(1):223-237.

③Shang NJ#, Ding MJ#, Dai MX, Si HL, Li SG,Zhao GY*: Biodegradation of malachite green by an endophytic bacteriumKlebsiella aerogenesS27 involving a novel oxidoreductase.Applied Microbiology and Biotechnology2019, 103(5):2141-2153.

Zhao GY#, Shao F#, Zhang M, Zhang XJ, Wang JY, Fan SJ*, Dai MX*:Luteimonas rhizosphaeraesp. nov., isolated from the rhizosphere ofTriticum aestivumL.International Journal of Systematic and Evolutionary Microbiology2018, 68(4):1197-1203.

⑤Shang NJ, Zhu QQ, Dai MX,Zhao GY*: Complete genome sequence of the heavy-metal-tolerant endophytic type strain ofSalinicola tamaricis.Genome Announcements2018, 6(16):e00358-00318.

Zhao GY#, Zhao LY#, Xia ZJ, Zhu JL, Liu D, Liu CY, Chen XL, Zhang YZ, Zhang XY*, Dai MX*:Salinicola tamaricissp. nov., a heavy-metal-tolerant, endophytic bacterium isolated from the halophyteTamarix chinensisLour.International Journal of Systematic and Evolutionary Microbiology2017, 67(6):1813-1819.

⑦Casella S, Huang F, Mason D,Zhao GY, Johnson GN, Mullineaux CW, Liu LN*: Dissecting the native architecture and dynamics of cyanobacterial photosynthetic machinery.Molecular Plant2017, 10(11):1434-1448.

⑧Xia ZJ, Wu HZ, Cui CX, Chen Q,Zhao GY, Wang HX, Dai MX*:Larsenimonas suaedaesp. nov., a moderately halophilic, endophytic bacterium isolated from the euhalophyteSuaeda salsa.International Journal of Systematic and Evolutionary Microbiology2016, 66(8):2952-2958.

Zhao GY#, Fan JY#, Hua CP, Yan W, Chen C, Lu YH, Jiao RH*, Tan RX*: Resveratrol improves fungal ribosylation capacity through a unique mechanism.RSC Advances2015, 5(8):5657-5663.

⑩Tian Y#,Zhao GY#, Fang W#, Xu Q, Tan RX*: Δ10(E)-Sphingolipid Desaturase involved in Fusaruside mycosynthesis and stress adaptation inFusarium graminearum.Scientific Reports2015, 5:10486.

⑪Song YN, Jiao RH, Zhang WJ,Zhao GY, Dou H, Jiang R, Zhang AH, Hou YY, Bi SF, Ge HM*, Tan RX*: New ansamycin derivatives generated by simultaneous mutasynthesis.Organic Letters2015, 17(3):556-559.

⑫Ran LY#, Su HN#,Zhao GY#, Gao X, Zhou MY, Wang P, Zhao HL, Xie BB, Zhang XY, Chen XL, Zhou BC, Zhang YZ*: Structural and mechanistic insights into collagen degradation by a bacterial collagenolytic serine protease in the subtilisin family.Molecular Microbiology2013, 90(5):997-1010.

⑬Qiao HS, Chen XQ, Xu LF, Wang JJ,Zhao GY, Hou YY, Ge HM, Tan RX*, Li EG*: Antitumor effects of naturally occurring oligomeric resveratrol derivatives.FASEB Journal2013, 27(11):4561-4571.

⑭Fang W#, Ji S#, Jiang N#, Wang W#,Zhao GY#, Zhang S, Ge HM, Xu Q, Zhang AH, Zhang YL, Song YC, Zhang J, Tan RX*: Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols inDaldinia eschscholzii.Nature Communications2012, 3:1039.(并列第一作者按姓氏排名)

Zhao GY#, Zhou MY, Zhao HL, Chen XL*, Xie BB, Zhang XY, He HL, Zhou BC, Zhang YZ: Tenderization effect of cold-adapted collagenolytic protease MCP-01 on beef meat at low temperature and its mechanism.Food Chemistry2012, 134(4):1738-1744.

⑯Wang YK#,Zhao GY#, Li Y, Chen XL, Xie BB, Su HN, Lv YH, He HL, Liu H, Hu J, Zhou BC, Zhang YZ*: Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep seaPseudoalteromonassp. SM9913: binding of the PKD domain to collagen results in collagen swelling but does not unwind the collagen triple helix.The Journal of Biological Chemistry2010, 285(19):14285-14291.

Zhao GY#, Chen XL#, Zhao HL, Xie BB, Zhou BC, Zhang YZ*: Hydrolysis of insoluble collagen by deseasin MCP-01 from deep-seaPseudoalteromonassp. SM9913: collagenolytic characters, collagen-binding ability of C-terminal polycystic kidney disease domain, and implication for its novel role in deep-sea sedimentary particulate organic nitrogen degradation.The Journal of Biological Chemistry2008, 283(52):36100-36107.

⑱参编《中国学科发展战略-化学生物学》(科学出版社),ISBN9787030433992,出版时间2015-4-1。

2.授权专利:

①赵国琰,尚念杰,一株在高盐环境下降解孔雀石绿的产气肠杆菌,专利号:ZL 2017 1 1180830.7,授权公告号:CN 107858303 B,授权日:2020. 02.07。

②赵国琰,尚念杰,丁梦娇,一种消煮专用圆底烧瓶放置架,授权号:CN 207856954 U.授权日: 2018.09.14。

3.教学成果

2020/11指导研究生获省级硕士优秀毕业论文

2017/11指导本科生获全国大学生生命科学竞赛三等奖

2017/10指导本科生获国家级大学生创新创业计划项目

2016/10指导本科生获国家级大学生创新创业计划项目