张凡

日期: 2021/01/27 作者: 浏览量:


一、个人简介

张凡,教授,博士生导师,2007年获浙江大学博士学位,同年至山东师范大学生命科学学院动物学教研室工作至今。担任山东省动物学会理事,山东预防医学会媒介生物学及控制分会委员会常务委员,2019年-2020年美国北卡罗来纳州立大学访问学者。主讲普通动物学、动物学试验、保护生物学、行为生态学及生物标本制作等7门课程,承担国家首批一流课程建设(普通动物学)及省,院校级教改项目14项,指导本科生多次获“挑战杯”大学生课外学术科技作品竞赛及创业大赛国家级奖项。承担国家自然科学基金、国家重大科技专项子课题及其他省部级项目10项,发表论文40余篇,其中SCI论文收录30余篇,授权国家发明专利8项,参编教材4部,担任Frontiers in Physiology等SCI杂志Review Editor。

二、研究方向

从事病媒昆虫学研究,现阶段的科研工作主要集中在德国小蠊肠道微生态,害虫生物防治(昆虫病原微生物)以及抗药性分子机制方面。

三、承担项目

1.国家自然科学基金:德国小蠊肠道菌分泌的活性肽抗白僵菌感染的作用机制研究(81572027),项目起止年月:2016年01月至2019年12月 主持

2.山东省重点研发计划(公益类):新型系列复配生物灭蟑毒饵的研制和开发(2017GSF221012),项目起止年月:2018年01月至2020年12月 主持

3.山东省自然科学基金:高效氯氰菊酯抗性对德国小蠊生物适合度的影响及其机理研究(ZR2012CQ040)项目起止年月:2012年07月至2015年07月 主持

4.山东省高等学校科技发展项目:德国小蠊抗高效氯氰菊酯相关蛋白的分离及鉴定(J11LC13)项目起止年月:2011年12月至2014年12月 主持

5.山东省医药卫生科技发展计划项目:德国小蠊抗药性机理及蛋白分子标记物的筛选研究(2011HZ056)、2011.01-2013.12、主持

6.国家自然科学基金:纤毛在早产儿视网膜早期病变中的病理学功能及分子机制 (31701169)项目起止年月:2018年1月至2020年12月 第二位

7.国家重大课题专项子课题:人工调控下自然湿地生态恢复技术与工程示范(No.20082x07209-006)、2008.12-2009.12、参与

8.国家自然科学基金:非吸烟女性肺癌患者唾液基因标志物图谱与遗传和环境因素相关性的研究((31471202),项目起止年月:2014年01月至2017年12月 参与

9.国家自然科学基金:抗辐射菌DNA损伤修复基因的表达及在细胞损伤检测中的应用(30770650)、2008.01-2008.12、参与

10.国家自然科学基金:家蚕微粒子虫发芽抑制因子的基因克隆与分析(30471311)、2005.01-2007.12、参与

四、教学科研成果(论文、专著、专利等)

1.Jiang M, Dong FY, Pan XY, Zhang YN*,Zhang F*. Boric acid was orally toxic to different instars ofBlattella germanica(L.) (Blattodea: Blattellidae) and caused dysbiosis of the, gut microbiota.Pesticide Biochemistry and Physiology. December 2020,https://doi.org/10.1016/j.pestbp.2020.104756(通讯作者)

2.Yang R A, Zhang MJ,Coby Schal,Cai T,Zhang F*. Boric acid enhances Metarhizium anisopliaevirulence in Blattella germanica (L.) by disrupting the gut and altering its microbial community.Biological Control.Volume 152, January 2021, 104430(通讯作者)

3.Pan X Y, Wang X J ,Zhang F*. New Insights into Cockroach Control: Using Functional Diversity of Blattella germanica Symbionts. Insects. 2020 (通讯作者)

4.Chao Y,Wang MY,Dai W,Wang XJ*,Zhang F*.Synergism Between Hydramethylnon and Metarhizium anisopliae and Their Influence on the Gut Microbiome of Blattella germanica (L.).Insects.Inpress, 2020 (通讯作者)

5.Li YR, Coby Schal, Pan XY, Huang YH*,Zhang F *.Effects of Antibiotics on the Dynamic Balance of Bacteria and Fungi in the Gut of the German Cockroach.J Econ Entomol. In press,2020 (通讯作者)

6.Cai T, Huang YH,Zhang F*.Ovarian morphological features and proteome reveal fecundity fitness disadvantages in β-cypermethrin-resistant strains of Blattella germanica (L.) (Blattodea: Blattellidae).Pestic Biochem Physiol ,In press,2020 (通讯作者)

7. Zhang F,Yang C.L, Zhang X.C, Zhu H.Y, Huang Y.H, et al.Isolation of an anti-entomopathogenic fungal protein secreted from Pseudomonas aeruginosa BGf-2: an intestinal bacteriam of Blattella germanica (L.),Journal of Invertebrate Pathology,2020(in press)

8.Zhang F*,Yang R A. Life history and functional capacity of the microbiome are altered in beta-cypermethrin-resistant cockroaches.International Journal for Parasiology 49(9), 715-723, 2019.

9.Pan X.Y,Zhang F*.Advances in Biological Control of the German cockroach, Blattella germanica (L.).Biological Control,https://doi.org/10.1016/j.biocontrol. 2019.104104,2019 (通讯作者)

10.Zhang XC,Li XX,Gong YW,Li YR,Zhang KL,Huang YH,Zhang F*, Isolation, Identification, and Virulence of a New Metarhizium anisopliae Strain on the German Cockroach.J Econ Entomol.111(6):2611-2616,2018 doi: 10.1093/jee/toy280, 2019 (通讯作者)

11.Yang C.L, Zhu H.Y,Zhang F*. Comparative Proteomics Analysis Between the Short-Term Stress and Long-Term Adaptation of the Blattella germanica (Blattodea: Blattellidae) in Response to Beta-Cypermethrin. J Econ Entomol .Doi : 10.1093/jee/toz047, 2019(通讯作者)

12.Zhang X.C,Zhang F*.The Potential Control Strategies Based on the Interaction Between Indoor Cockroaches and Their Symbionts in China.Advances in Insect Physiology,55, 55-122, 2018(通讯作者)

13.Zhang F, Sun X X, Zhang X C et al. The interactions between gut microbiota and

entomopathogenic fungi: a potential approach for biological control ofBlattella germanica(L.). Pest Manag Sci, 74(2):438-447, 2018

14.Zhang F,Wang X.J, Huang Y.H,Zhao Z.G, Zhang S.S, Gong X.S, Xie L, Kang D.M*, Jing X*.Differential Expression of Hemolymph Proteins between Susceptible and Insecticide-ResistantBlattella Germanica. Environmental Entomology, 43(4): 1117-1123, 2014

15.Zhang F,Huang Y.H, Liu S.Z, Zhang L, Li B.T, Zhao X.X, Fu Y, Liu J.J, Zhang X.X*.Pseudomonas reactans, a Bacterial Strain Isolated from the Intestinal Flora ofBlattella Germanicawith Anti-Beauveria bassianaActivity. Environmental Entomology, 42(3):453-459, 2013

16.Huang Y.H, Wang X.J,Zhang F*,Huo X.B*, Fu R.S, Sun W.B,Kang D.M, Jing X. The Identification of a Bacterial Strain BGI-1 (Intestinal Bacteria ofBlattella Germanica) and its Anti-Entomopathogenic Fungi Activity. Journal of Economic Entomology, 106(1):43-49, 2013(通讯作者)

17.Zhang F, Lu X*, Kumar V.S, Zhu H, Chen H, Chen Z, Hong J. Effects of a novel anti-exospore monoclonal antibody on microsporidialNosema bombycisgermination and reproductionin vitro. Parasitology, 134: 1551-1558, 2007

18.Xu JW,Zhu XY,ChaoQJ,Zhang YJ,Yang YX,Wang RR,Zhang Y,Xie MZ,Ge YT,Wu XL,Zhang F,Zhang YN,Ji L,Xu L. Chemosensory Gene Families in the Oligophagous Pear Pest Cacopsylla chinensis (Hemiptera: Psyllidae).Insects.10(6), 2019

19. He P, Ma Y.F, Wang M.M,Wang H, Dewer Y, Abd El-Ghany N. M, Chen G.L,Yang G.Q,Zhang F,He M. Silencing the odorant coreceptor (Orco) disrupts sex pheromonal communication and feeding responses in Blattella germanica:toward an alternative target for controlling insect-transmitted human diseases.Pest Manag Sci.2020 Nov17. doi: 10.1002/ps.6187. [Epub ahead of print]

20.Zhang YN,Xu JW,Zhang XC,Zhang F,Wu XM etal.Organophosphorus insecticide interacts with the pheromone-binding proteins of Athetis lepigone: Implication for olfactory dysfunctionJournal of Hazardous Materials,Volume 397, 2020, 122777

21.Zhu XY, Xu JW, Wang DY, Li M, Zhang NN,Zhang F, Zhang YN, Mang DZ et al.

Analysis of chemosensory genes in Semiothisa cinerearia reveals sex-specific contributions for type-II sex pheromone chemosensation.Genomics,Volume 112, Issue 6, 2020, Pages 3846-3855

22.Wang S, Xin C, Wu X, Shi J, Peng Z, Sun P, Wang Y, Xu S, Yang Y,Zhang F,Li J. Genetic characterization of Porcine circovirus type 2 from 2013 to 2018 in Shandong Province, China.Vet Med Sci.2019 Oct 16. doi: 10.1002/vms3.196

23.Li M,Yang Y,Yao Y,Xiang W,Han J,Wang Y,Bai P,Wang J,Zhu G,Man L,Zhang F,Pan L. Isolation and identification of attractants from the pupae of three lepidopteran species for the parasitoid Chouioia cunea Yang.Pest Manag Sci.2019 Dec 18. doi: 10.1002/ps.5724. [Epub ahead of print]

24.He P,Wang MM,Wang H,Ma YF,Yang S,Li SB,Li XG,Li S,Zhang F,Wang Q,Ran HN,Yang GQ,Dewer Y,He M.Genome-wide identification of chemosensory receptor genes in the small brown planthopper, Laodelphax striatellus.Genomics.2019 Nov 22. pii: S0888-7543(19)30796-7. doi: 10.1016/j.ygeno.2019.11.016. [Epub ahead of print]

25.He P, Mang D Z, Wan H,Zhang F, et al. Molecular characterization and functional analysis of a Spodoptera exigua ubiquitous carboxylesterase suggested it acted as a cuticle enzyme degradation of ester chemical stimulus[J]. Pesticide Biochemistry and Physiology, 2019

26.TAN Liu-gang, CHEN Zhao-kun, MA Xin-xin, HUANG Qing-hua, SUN Hai-ji,Zhang F,YANG Shao-hua, XU Chuan-tian, CUI Ning. Glycosylation of the hemagglutinin protein of H9N2 subtype avian influenza virus influences its replication and virulence in mice[J].Journal of Integrative Agriculture.Volume 18, Issue 7, July 2019, Pages 1443-1450

27.Zhao D,Liang L,Wang S,Nakao T,Li Y,Liu L,Guan Y,Fukuyama S,Bu Z,Kawaoka Y,Zhang F,Chen H.Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response.J Virol.Mar 13;91(7). pii: e02215-16. doi: 10.1128/JVI.02215-16, 2017

28.张凡*.德国小蠊抗药性机理的研究.生命的化学, 31(1):1-4 , 2011

29.张凡*.德国小蠊肠道菌BGI-17的鉴定及抗真菌研究.中国媒介生物学及控制杂志, 23(1):35-37,2012

30.黄艳红,张凡,付荣恕,刘树真,霍新北*.德国小蠊肠道菌群分离及抗真菌活性分析.中国公共卫生, 27(1):129-130,2011

31.刘浩,张凡,黄艳红,霍新北*.三种抗生素对德国小蠊肠道菌去除效果的研究.山东师范大学学报(自然科学版), 27(3):115-117,2012

32.黄艳红,霍新北,王钰雅,张凡*.五种德国小蠊全虫蛋白提取方法的效果比较.中国媒介生物学及控制杂志, 23 (3):209-211,2012 (通讯作者)

33.王学军,康殿民*,张凡,赵志刚.德国小蠊抗药性与乙酰胆碱酯酶、谷胱甘肽S-转移酶和超氧化物歧化酶活性关系的研究.中国媒介生物学及控制杂志,24 (2):135-137,2013

34.李六文,张宪翠,夏静,张硕,赵东芹,张凡*.去除共生菌对德国小蠊生物适合度的影响.山东师范大学学报(自然科学版),31(4):143-147,2016 (通讯作者)

35.施万里,杨繁,孙晓霞,卢洁,赵东芹,张凡*.多种抗生素对抗药性德国小蠊肠道菌去除效果的研究.内蒙古大学学报(自然科学版),2017 (通讯作者)

36.刘九榕,邵博文,周宇石,刘慧敏,阚硕,薄鹏飞,张凡*.一株沙雷氏菌的分离鉴定及其对德国小蠊的毒力测定.生物学通报.54(3),74-76,2019 (通讯作者)

发明专利:

发明专利1:一种用于蟑螂生物防治的病原真菌,申请号:201611044989.1,发文序号:2016112401973370

发明专利2:一株金龟子绿僵菌转基因菌株及其制备方法与应用,申请号:201410542584.5,发文序号:2014101500662930

发明专利3:一种以含有金龟子绿僵菌发酵液和氟蚁腙为主要活性成分的杀虫组合物,申请号:201710995446.6发文序号:2017102302328460申请日期:2017.10.23

发明专利4.一种复配生物杀虫剂及其制备方法和应用.申请号:201811118562.0发文序号:2018122600725540申请日期:2018.9.26

发明专利5.一种生物源杀虫组合物及应用。申请号:201910917042.4发文序号:20191223 00861720申请日期:2019.12.26

发明专利6.一种制备阿胶小分子低肽的方法。专利号:201710144390.3发文序号:2017031300460900申请日期:2017.03.10

发明专利7.一种生物源杀虫组合物及其应用。专利号:201910917042.4发文序号:2019122300861720申请日期:2019.12.26

发明专利8.一种复配生物杀虫剂及其制备方法。专利号:201910276798.5发文序号:2019040801555030申请日期:2019.04.08

五、获奖

指导本科生获2015年第九届挑战杯“创青春”˙青岛银行山东省大学生创业大赛金奖,国家银奖,2013年第十三届“挑战杯”山东省大学生课外学术科技作品竞赛省一等奖,2017年第十五届“挑战杯”大学生课外学术科技作品竞赛省特等奖,国家三等奖;2017年山东省第三届“互联网+”大学生创新创业大赛省银奖;至2020年,指导学生获国家大学生创新创业计划立项11项,国家级竞赛获奖5项,省级获奖20余项。