孙海基

日期: 2021/01/30 作者: 浏览量:


孙海基,男,教授,硕士生导师,博士生导师。2009年毕业于山东师范大学生物系获理学博士学位,2007年9月~2008年9月期间,在法国与世界卫生组织肿瘤研究署(IARC)进行课题合作研究。主要从事应激神经生物学、脑科学方面及肿瘤方面的研究。近几年已发表论文40余篇,SCI收录20余篇。主持国家自然科学基金面向项目、国家级公益性行业科研专项子课题、山东省自然科学基金及横向课题等多项。现任生命科学学院动物学硕士学位点负责人,脑功能障碍神经环路团队负责人。高校教材《人体解剖生理学实验教程》及《人体解剖生理学》的副主编,参与编写高教出版社的《人体动物生理学》。为山东省解剖学会及生理学会常务理事,中文核心期刊《生物医学工程研究》的编委。

研究方向:主要从事应激性胃肠功能功能紊乱的中枢和外周机制的研究。

承担项目:

1、国家自然科学基金面上项目,31672286,:延髓-迷走神经-肠脑环路在束缚-浸水应激致胃肠机能紊乱中的作用,2017/01-2020/12,主持。

2、山东省自然科学基金,ZR2013CM010、迷走复合体星形胶质细胞在束缚-浸水应激致胃黏膜损伤中的作用及与神经元的关系、2013/01-2016/12、主持。

3、国家级公益性行业(农业)科研专项子课题,201303069-07、谷子碎米黄酒生产技术研究与示范-谷子碎米黄酒品质分析及生理功效研究、2013/01-2017/12主持。

4、横向课题中药FKQJ药渣抗菌、抗炎作用的评价分析2014/10-2016/10,主持

教学科研成果

著作:

1《人体及动物生理学》第三版高等教育出版社2015参编

2《生理学实验释疑解难》 科学出版社2007参编

3《人体解剖生理学实验教程》科学出版社2014副主编

4《人体解剖生理学》科学出版社2015副主编

期刊论文:

1、Chen Z , Ding H , Shi Y ,Sun HJ. Exogenous Hydrogen Sulfide Within the Nucleus Ambiguus Inhibits Gastrointestinal Motility in Rats[J]. Frontiers in Physiology, 2020, 11:545184.

2、Zhao D Q , Xue H , Sun H J . Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion[J]. 2020.二区,通讯作者

3、Chen X , Jia Y , Zhang Y , et al. α5‐nAChR contributes to epithelial‐mesenchymal transition and metastasis by regulating Jab1/Csn5 signalling in lung cancer[J]. Journal of Cellular and Molecular Medicine, 2020, 24(4).二区,通讯作者

4、Sun H , Gao W , Li H , et al. Comparative study of the distribution of NOS‐positive neurons in pigeon intestine[J]. Anatomia, Histologia, Embryologia, 2020, 49(4).四区

5、Sun H , Sun X , Wang H , et al. Advances in salt tolerance molecular mechanism in tobacco plants[J]. Hereditas, 2020, 157.四区

6、Fan F, Yang M, Geng X, et al. Effects of Restraint Water-Immersion Stress-Induced Gastric Mucosal Damage on Astrocytes and Neurons in the Nucleus Raphe Magnus of Rats via the ERK1/2 Signaling Pathway[J]. Neurochemical research, 2019: 1-10.三区,通讯作者

7、Sun H, Zhao P, Liu W, et al. Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats.[J]. Scientific Reports, 2018, 8(1).三区

8、Astrocytes and Neurons in Locus Coeruleus Mediate Restraint Water Immersion tress-Induced Gastric Mucosal Damage Through the ERK1/2 Signaling Pathway.[J]. Neuroscience Letters, 2018.四区,通讯作者

9、Zhao P , Wang J , Zhao W , et al. Antifatigue and antiaging effects of Chinese rice wine in mice[J]. Food Science & Nutrition, 2018, 6.四区,通讯作者

10、Sun H J, Jia Y F, Ma X L. Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression[J]. Frontiers in Pharmacology, 2017, 8:573.SCI,二区,通讯作者

11、Sun H , Li R , Xu S , et al. Hypothalamic Astrocytes Respond to Gastric Mucosal Damage Induced by Restraint Water-Immersion Stress in Rat[J]. Frontiers in Behavioral Neuroscience, 2016, 10.二区

12、Jia, Yanfei,Haiji Sun,Wu, Hongqiao,Zhang, Huilin,Ma, Xiaoli.Nicotine InhibitsCisplatin-Induced Apoptosis via Regulating alpha5-nAChR/AKT Signaling in HumanGastric Cancer Cells.,PLoS One,2016,11(2)。二区,第一作者

13、Haiji Sun,Xiaoli Ma,α5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells,Experimental and ToxicologicPathology,2015。四区四区

14、Sun, Haiji,Liu, Zhen,Ma, Xiaoli,Interactions between astrocytesand neurons in the brainstem involved in restraint water immersionstress-induced gastric mucosal damage.,Neuroreport,2016,2。四区

15、Yingchao Shi, Ying Jia, Shanshan Zu, Yanfei Jia, Xueping Zhang,Haiji Sun* and Xiaoli Ma *.Sonic Hedgehog Signaling Molecules Expression in TGF-β1-Induced Chondrogenic Differentiation of Rat Mesenchymal Stem Cells In Vitro.Frontier and Future Development of Information Technology in Medicine and EducationLecture Notes in Electrical Engineering.269, 755-762,2014

16、Hai-Ji Sun#,Yun-Jian Liu#, Na Li, Zhi-Yong Sun, Hai-Wang Zhao, Chen Wang, Hui Li, Fang-Ming Ma,Song-Mei Shi, Xiao-Qiu Xu, Zhe-Yu Chen*,Shu-Hong Huang*.SublocalizationofRab23,amediatorofSonichedgehogsignaling pathway, in hepatocellular carcinoma cell lines[J]. Molecular medicine reports, 6(6): 1276-1280,2012,四区

17、Xiaoli Ma,Xueping Zhang,Yanfei Jia,Shanshan Zu,Shuyi Han,Dongjie Xiao,Haiji Sun*,Yunshan Wang*.Dexamethasone induces osteogenesis via regulation of Hedgehog signaling molecules in rat mesenchymal stem cells.Int Orthop. 37,1399–1404,2013

18、Xiaoli Ma,Shanshan Zu,Yanfei Jia,Yan Zheng,Shuyi Han,Hua Liu,Dongjie Xiao,Yunshan Wang* ,Xueping Zhang,Haiji Sun* ;Liguo An.Differential SHH and IHH expression during osteogenesis induced by Dexamethasone in rat bone marrow mesenchymal cells[C].Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on. IEEE, 3: 1204-1208,2011.

19、Xiaoli Ma ,Yun ZhaoYunshan WangXiuping ZhangQian ZhouHaiji Sun*,Liguo AnXueping Zhang.Mecamylamine Affects Cell Proliferation and Adhesion of Lung Cancer in Vitro.Biomedical Engineering and Informatics (BMEI), 3rd International Conference.IEEE, 5: 2078-2080,2010.

20、Haiji Sun,Liguo An,Yun Zhao,Xiaoli Ma,Yunshan Wang,Yanfei Jia,Yan Zheng.Dongjie Xiao.CHRNA5 Variants Related to Nicotine Sensitivity in Lung Cancer in Vitro.Biomedical Engineering and Informatics (BMEI), 3rd International Conference.IEEE, 5: 001-2003.,2010.

21、Ma X, Rousseau V, Sun H, Lantuejoul S, Filipits M, Pirker R, Popper H, Mendiboure J, Vataire AL, Le Chevalier T, Soria JC, Brambilla E, Dunant A, Hainaut P*; IALT-Bio working group. Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer. Mol Oncol. 2014 Jan 15. pii: S1574-7891(13)00187-7. doi: 10.1016/j.molonc.2013.12.015. [Epub ahead of print]

22、王聪,赵盼,周亚男,等.黄酒通过肠肌间神经丛抑制大鼠离体小肠的收缩[J].食品科学, 2019, 40(09):181-186.

23、黄酒通过肠肌间神经丛抑制大鼠离体小肠的收缩[J/OL].食品科学EI收录 ,孙海基

24、 秦雪,刘真,王璟,仝令印,孙海基.大鼠脑干星形胶质细胞在应激性胃黏膜损伤中的作用[J].生物医学工程研究,2016,35(4)

25、 时颖超,李瑞生,李佳颖,范方程,孙海基*.石杉碱甲对急性炎症小鼠室旁核和脑干c-Fos和GFAP表达的影响.河南师范大学学报(自然科学版)(中文核心期刊),42(1):105-110,2014

26、刘真,马晓丽,夏甜甜,孙海基*.尼古丁对小鼠镇痛作用的研究[J].时珍国医国药(中文核心期刊), (2): 279-280,2013.

27、姜冬峰,马晓丽,孙海基*.尼古丁和六烃季铵对小鼠急性炎症的影响[J].山东师范大学学报:自然科学版, 26(3): 101-103,2011,.

28、张雪萍,吕明明,李霞,孙海基*.尼古丁对药物性胃溃疡影响的实验研究[J].食品与药品, , 13(1): 30-32,2011.

29、李霞,李文文,张雪萍,陆长亮,孙海基*.尼古丁对小鼠应激性胃溃疡影响的研究[J].生物医学工程研究, 2010, 29(003): 168-171.

30、赵东芹,孙海基,姚旭东,等.束缚-浸水应激大鼠下丘脑前部,延髓内脏带突触可塑性的变化[J].神经解剖学杂志, 28(004): 352-358,2012.