一、 个人简介

常化松，男，博士，讲师。2024年6月，毕业于山东师范大学，获理学博士学位。目前于动物病毒学团队从事科研工作。以第一作者或并列第一作者在《Cellular & Molecular Immunology》《Journal of Virology》等期刊上发表SCI论文5篇。获得国家发明专利1项。

   二、研究方向

天然免疫系统是宿主抵御病原体的第一道防线，本课题组聚焦于解析动物病毒与宿主抗病毒天然免疫的互作机制，具体研究包括：

（1）病毒入侵机制：揭示病毒入侵宿主的关键分子事件及其调控机制；

（2）病毒复制调控：运用高通量测序等技术，系统性鉴定调控病毒复制的宿主因子并阐明其作用机制，旨在为抗病毒药物研发提供新靶点和理论支撑。

   三、承担项目

国家自然科学基金面上项目：PBLD通过上调MAVS抑制牛流行热病毒复制的分子机制研究（32373000），2024.01-2027.12，参与。

   四、科研成果

1. Huasong Chang^#, Peili Hou^#, Xuefeng Wang^#, Aibiao Xiang, Hao Wu, Wenjing Qi, Rukun Yang, Xue Wang, Xingyu Li, Wenqi He, Guimin Zhao, Weiyang Sun, Tiecheng Wang, Daniel Chang He, Hongmei Wang^*, Yuwei Gao^*, Hongbin He^*. (2023). CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation. Cellular & molecular immunology, 20(12), 1457–1471.

2. Huasong Chang^#, Hao Wu^#, Peili Ho, Muhammad Aizaz, Rukun Yang, Aibiao Xiang, Wenjing Qi, Hongbin He^*, Hongmei Wang^*. (2023). DLG1 promotes the antiviral innate immune response by inhibiting p62-mediated autophagic degradation of IKKε. Journal of virology, 97(12), e0150123.

3. Huasong Chang, Wenwen Yuan, Haizhu Wu, Xusheng Yin, Hongzhuan Xuan^*. Bioactive components and mechanisms of Chinese poplar propolis alleviates oxidized low-density lipoprotein-induced endothelial cells injury. BMC Complement Altern Med. 2018;18(1):142.

4. Huasong Chang^#, Yuehua Wang^#, Xusheng Yin, Xinying Liu, Hongzhuan Xuan^*. Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy. BMC Complement Altern Med. 2017;17(1):471.

5. Wenwen Yuan^#, Huasong Chang^#, Xinying Liu, Shiqiang Wang, Hui Liu, Hongzhuan Xuan^*. Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3K/Akt/mTOR-Mediated Nrf2/HO-1 Pathway. Evid Based Complement Alternat Med. 2019:5789574.

6. Xingyu Li^#, Peili Hou^#, Wenqing Ma^#, Xuefeng Wang^#, Hongmei Wang^*, Zhangping Yu, Huasong Chang, Tiecheng Wang, Song Jin, Xue Wang, Wenqi Wang, Yudong Zhao, Yong Zhao, Chunqing Xu, Xiaomei Ma, Yuwei Gao^*, Hongbin He^*. SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy. Cell Mol Immunol. 2022 Jan;19(1):67-78.

7. Peili Hou^#, Xuefeng Wang^#, Hongmei Wang^#*, Tiecheng Wang, Zhangping Yu, Chunqing Xu, Yudong Zhao, Wenqi Wang, Yong Zhao, Fengyun Chu, Huasong Chang, Hongchao Zhu, Jiahui Lu, Fuzhen Zhang, Xue Liang, Xingyu Li, Song Wang, Yuwei Gao^*, Hongbin He^*. The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication. Autophagy, 19(2), 551–569.

8. Hongzhuan Xuan, Wenwen Yuan, Huasong Chang, Minmin Liu, Fuliang Hu^*. Anti-inflammatory effects of Chinese propolis in lipopolysaccharide-stimulated human umbilical vein endothelial cells by suppressing autophagy and MAPK/NF-κB signaling pathway. Inflammopharmacology. 2019;27(3):561-571.

9. 陈义；常化松；孙明辉；王琦；马雪娇；陈春雷。一种牙髓干细胞冻存保护液和牙髓干细胞冻存方法，国家发明专利，专利授权号：CN112998008B，授权日期：2021-12-21。

   五、联系方式

邮箱：changhuasong@sdnu.edu.cn